HitGen will be responsible for the design and synthesis of DNA encoded library base on partner's specification.
☆ Vast number of molecules：The libraries containing millions to billions of highly diverse, drug-like small molecules and macrocycles can be designed and synthesized.
☆ Quick synthesis: Libraries containing millions to billions of compounds can be produced within 3 months.
☆ Highly diverse and drug-like molecules: Tens of thousands of building-blocks, large coverage of chemical space, controllable physico-chemical properties.
☆ Highly economic synthesis: One round synthesis provides library materials enough for more than 1,000 incubations.
☆ High synthesis quality of DELs: Complete inspection and quality assurance system, strict quality controls.
☆ Environment friendly: Synthesis of millions to billions molecules only requires several liters of solvents.
☆ Flexible modes of collaboration：Customer’s proprietary libraries or shared libraries could be designed and synthesized.
☆ Small biological target amount required: Typically 3 mg biological target is sufficient for the entire screening, significantly reduce target preparation time and cost
☆ Shorter screening time required: The entire DEL screening typically completes within 3 months, including Off-DNA compound validation
☆ Multi- sample/condition screening in parallel : DEL screening have capability of running multiple targets or multiple conditions at the same time, generating hit selectivity information during the screening
☆ High throughput on affinity based screening: Affinity based DEL screening has particular high throughput on protein-protein interaction targets
HitGen provides other specialized services for drug discovery, to meet specific needs of each potential partner.
☆ Custom synthesis of biomacromolecule such as RNA/DNA, RNA/DNA modification, RNA/DNA conjugate glycoside and nucleoside compound;
☆ Custom synthesis of normal chemical compound with specific structure;
☆ Lead optimization;
☆ High-throughput sequencing;
☆ Protein/enzyme/cell-based assay activity;
☆ Protein expression, purification and crystallization.
HitGen initiates a number of drug discovery projects. These projects can be the subject of collaboration, which cover the areas of oncology, cardiovascular, inflammation and respiratory, etc.
☆ Flexible model of collaboration;
☆ Projects at different stages of research process can have different model of collaboration;
☆ Projects can be for out-licensing, risk sharing and co-development.