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On-DNA Derivatization of Quinoxalin-2-ones by Visible-Light-Triggered Alkylation with Carboxylic Acids 发布时间:2021-08-04

ABSTRACT: An efficient visible-light-induced alkylation of DNA-tagged quinoxaline-2-ones was described. The methodology

demonstrated moderate-to-excellent conversions under mild conditions. The reaction was found to be tolerant with both Nprotected

α-amino acids and aliphatic carboxylic acids and could be applied to the synthesis of focused DNA-encoded quinoxalin-2-

one libraries.


Bioconjug Chem:On-DNA Derivatization of Quinoxalin-2-ones by Visible-Light-Triggered Alkylation with Carboxylic Acids

link:https://doi.org/10.1021/acs.bioconjchem.1c00346


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