HitGen's chemistry business adheres to the philosophy of high quality, efficiency and continuous innovation, providing global partners with effective and competitively cost-efficient chemical solutions.
High - Throughput Synthesis Service Introduction
In the field of modern drug research and development, high - throughput synthesis technology is leading an efficiency revolution. We innovatively integrate the outstanding features of combinatorial chemistry and parallel synthesis into the conventional synthetic chemistry process, aiming to achieve high - throughput synthesis of complex drug molecules and fully promote the efficiency of compound synthesis and delivery to a new height. Based on rich past experience, the successful implementation of high - throughput synthesis not only relies on the full preparation of a large number of synthetic reagents and related consumables, but also inseparably depends on the elaborate design of the corresponding synthetic routes. These two aspects complement each other and jointly form a solid foundation for efficient synthesis.
After years of in - depth cultivation and accumulation, HitGen has already possessed all the key elements required for parallel synthesis, demonstrating significant advantages:
Core Platform - DNA - Encoded Compound Library: HitGen has constructed a large - scale DNA - encoded compound library, covering one trillion compounds, and has stocked more than 100,000 kinds of reagents, among which there are a large number of rare carbon skeletons. This huge and rich resource library provides a solid material basis for high - throughput synthesis. It is like building a treasure trove of raw materials for drug research and development, greatly expanding the possibilities of compound synthesis.
Innovative Parallel Synthesis Design Concept: HitGen has broken through the limitations of traditional parallel synthesis design. Adhering to the principle of making full use of common skeletons and parent nuclei, we have established a mature coding system for the general skeletons of reactions. This system can accurately analyze the sequences of specified series of compounds and quickly output the corresponding compound structures. It is like an intelligent designer, efficiently and accurately providing a clear blueprint for synthesis work, and significantly enhancing the scientificity and efficiency of synthetic route planning.
Full - Stack Automated Synthesis Platform: HitGen has independently designed and successfully built a full - stack automated synthesis platform, realizing end - to - end fully automated synthesis from raw materials to final products. This groundbreaking achievement has made HitGen stand out in the global context and become one of the few platforms capable of providing one - stop automated synthesis services. Relying on the powerful efficiency of this platform, in the past few months, more than 80,000 different types of small - molecule compounds have been efficiently synthesized. These compounds cover a wide range of molecular types, including heterocycles, peptides, macrocycles, and molecular glues, fully demonstrating the excellent synthesis ability and flexibility of the platform.
Similar to the traditional chemical service model, HitGen provides customers with comprehensive and attentive services:
Regular Synthesis Progress Updates: We regularly update the synthesis progress every two weeks to ensure that customers can track the synthesis progress of corresponding projects in a timely and accurate manner. It is like equipping customers with an exclusive "progress announcer", keeping the project progress under control.
Synthesis Route Reports: We provide detailed briefings on the adopted synthesis routes in real - time, enabling customers to clearly understand the key steps and technical paths in the synthesis process and providing a strong basis for customers' decision - making.
Patentable Experimental Reports: We provide detailed reports containing experimental procedures and post - treatment details. The report content is detailed and standardized, with patentable value, firmly laying the foundation for the protection of customers' scientific research achievements.
Analysis Data: We provide comprehensive analysis data such as 1H - NMR spectra, LC - MS spectra, and HPLC analysis spectra, accurately characterizing the synthesized compounds from multiple perspectives and providing key information for compound quality evaluation and further research.
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