HitGen-Protein Degradation

Protein Degradation

HitGen's Targeted Protein Degradation Platform integrates DEL, PROTAC synthesis, and biological validation to address historically undruggable targets.

Protein Degradation: HitGen use DEL technology to identify small molecule ligands with affinity, where DNA tags provide connection sites for linker attachment.

E3 Ligases and Their Binders: HitGen is working on identifying novel E3 ligases, and expanding the E3 ligase and binder tool box to be used for both external and internal TPD projects.

Discovery of Molecular Glue Degraders: Several dozens of purified E3s have been expressed, purified and screened against HitGen DELs, yielding many specific binders especially for those E3s without any binders reported. Some of these E3 binders have been found with potential molecular glue function.

Discovery of Proteolysis-targeting chimeras (PROTACs): HitGen has successfully screened 41 target types. To shorten the linker optimization process, HitGen has developed a ternary complex-based PROTAC-DEL screening technology and a high-throughput PROTAC synthesis platform leveraging diverse linker repositories.

Protein Degrader Evaluation: HitGen possesses extensive expertise in biochemistry, biophysics, cell biology, in vivo pharmacokinetics, and pharmacodynamic evaluation. Given the characteristics of protein degradation technologies, HitGen has developed a series of relevant assays to support the development of protein degraders.

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For more details on how we can advance your innovative drug discovery projects

Sites: HitGen Inc.

Building C2, NO.8, Huigu 1st East Road
Tianfu International Bio-Town,
Shuangliu District, Chengdu City,
Sichuan Province,P.R. China

Tel : +86-28-8519-7385

HitGen Pharmaceuticals Inc.(US Subsidiary)

Tel : +1-(508)-840-9646

Vernalis (R&D) Limited (UK Subsidiary)

Granta Park,Great Abington
Cambridge,CB21 6GB
United Kingdom

Tel : +44(0)1223-895555

Contact: Business Inquiry : bd@hitgen.com; Investor Relations : investors@hitgen.com; Media : media@hitgen.com; Career and Jobs : human.resources@hitgen.com

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