Welcome to HitGen

Advancing Innovative Drug Discovery

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Drug discovery, it's in our DNA.

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Enable Innovative Drug Discovery with DEL, FBDD and SBDD

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Capabilities & Services

Enabling Innovative Drug Discovery with Advanced Technologies

  • DNA-encoded Library
    DNA-encoded Library
  • Fragment-based Drug Discovery
    FBDD/SBDD
  • Chemistry
    Chemistry
  • Bioscience
    Bioscience
  • Computational Sciences and Informatics
    Computational Sciences and Informatics
  • Structural Biology
    Structural Biology
  • Pre-clinical Studies
    Pre-clinical Studies
  • Clinical Development
    Clinical Development

Therapeutic Areas

Integrated One-stop Drug Discovery Platform   Accelerating Project with High Efficiency

  • Oncology and Immuno-oncology
    Oncology and Immuno-oncology
  • Inflammatory and Autoimmune Diseases
    Inflammatory and Autoimmune Diseases
  • Ophthalmology
    Ophthalmology
  • Infectious Diseases
    Infectious Diseases
  • Metabolic Diseases
    Metabolic Diseases
  • Cardiovascular Diseases
    Cardiovascular Diseases
HitGen Inc. is a rapidly developing biotech company
The discovery and development of novel medicines and agrochemicals
>1 Trillion

DNA encoded compounds

>6,000

novel drug/target complex structures for FBDD/SBDD

About Us

HitGen Inc. is a rapidly developing biotech company headquartered in Chengdu, China, with subsidiaries in Cambridge, UK and Houston, USA. It became a publicly listed company in Shanghai Stock Exchange in April 2020 (ticker code 688222.SH).  HitGen has established a drug discovery research platform for small molecules and nucleic acid drugs centered on the design, synthesis and screening of DNA encoded chemical libraries (DELs), fragment-based drug discovery (FBDD) and structure-based drug design (SBDD) technologies. HitGen's DELs currently contains more than 1 trillion novel, diverse, drug-like small molecules and macrocyclic compounds. These compounds are members of DELs synthesized from many hundreds of distinct chemical scaffolds, designed with tractable chemistry, and have yielded proven results for the discovery of small molecule leads against both precedented and unprecedented classes of biological targets.


Through its acquisition of Cambridge UK based Vernalis R&D Ltd, a leader in FBDD/SBDD, HitGen now has a research team of over 500 scientists and offers a full set of research capabilities from recombinant protein expression and purification, structural biology, assay development, screening, DEL synthesis, nucleic acid and small molecule chemical synthesis, computational and medicinal chemistry, biochemistry and biophysics, cell biology, in vivo pharmacology, DMPK, CMC, etc., to enable drug discovery research from target gene to IND filing.


HitGen operates a flexible business model, ranging from a single capability-based fee for services (FFS,e.g., protein expression and purification, structural biology, bioinformatics, computational chemistry, medicinal chemistry, nucleic and organic chemistry, analytical chemistry, biophysics, PK/PD, etc.), DEL screening, DEL design, synthesis and characterization, integrated drug discovery projects, risk sharing projects, collaborative ventures to program out-licensing. HitGen has approximately 20 in-house drug discovery programs at different stages of research & development. HitGen is collaborating with pharmaceutical, biotech and chemical companies, foundations and research institutes in North America, Europe, Asia, Africa and Australia to enable the discovery and development of novel medicines and agrochemicals.


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Collaboration Partner

Latest News

  • 13 May 2021

    Coming Soon! Whitepaper: Advancing Drug Discovery through DNA-Encoded Library Technology!

    Since its concept was conceived in 1992, DNA-encoded chemical libraries (DELs) have evolved into a valuable technology for hit identification in drug discovery.
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  • 06 April 2021

    HitGen and BioAge Announce Research Progress in DNA-Encoded Library Based Drug Discovery Research Collaboration

    On 6th April 2021, CHENGDU, China-- Shanghai Stock Exchange listed biotech company HitGen Inc. (“HitGen”) announced important research progress in a collaboration with BioAge Labs, Inc. (“BioAge”), a private biotechnology company developing targeted small molecules for the treatment of diseases of aging. The companies have conducted collaborative research to identify and develop novel small-molecule compounds against a high-value and challenging biological target that is a critical component of the innate immune system. Dysregulation of this target is closely linked to the underlying cause of severe diseases in elderly humans, such as Alzheimer's and cardiovascular disease.
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  • 10 March 2021

    Lipigon expands collaboration with HitGen by selecting second target

    Chengdu, China March 10th, 2021 Lipigon Pharmaceuticals AB (”Lipigon”), developer of therapeutics for lipid-related diseases, today announced that the company has expanded its agreement with the Shanghai STAR listed company HitGen Inc. (”HitGen”) to include a second novel target. With joint efforts, the aim is to develop a treatment for cardiometabolic disease.
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