HitGen has established a drug discovery research platform for small molecules and nucleic acid drugs centered on the design, synthesis and screening of DNA encoded chemical libraries (DELs), fragment-based drug discovery (FBDD) and structure-based drug design (SBDD) technologies.
Abstract
Herein, we report a method that enables the synthesis of carbohydrate–DNA conjugates by radical addition. Key to the success is the use of readily available, bench-stable, and unprotected glycosyl sulfinates as precursors to glycosyl radicals. The redox neutral reaction proceeds under mild and simple conditions and tolerates a broad substrate scope. A small library of carbohydrate–DNA conjugates was prepared.
Org Lett:Carbohydrate−DNA Conjugation Enabled by Glycosyl Radicals Generated from Glycosyl Sulfinates
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