Conjugate For Custom-synthesized Multivalent Linkers

Nucleic acid drugs are targeted therapeutics designed to act with precision by modulating gene expression or interfering with pathogenic protein synthesis. However, many types of oligonucleotides have disadvantages such as poor targeting capability, inadequate in vivo stability, and inefficient transmembrane ability.

At HitGen, we leverage multivalent conjugation strategies to overcome these bottlenecks and deliver enhanced performance for your programs:

Increased payload capacity:

Achieve site-specific DAR values of 4, 6, or 8, critical for effective delivery of drugs requiring high concentrations.

Enhanced binding avidity:

Exploit multivalent interactions for significantly stronger target receptor binding than monovalent formats.

Improved precision:

Recognize overexpressed receptor clusters on diseased cells, enabling better differentiation between cancer and healthy cells.

Enhanced stability:

Multivalent scaffolds (e.g., dendrimers) improve colloidal stability and reduce aggregation risk vs. traditional methods.

List of available Linkers

HPLC of ligand oligo conjugate

HPLC of Lipid oligo conjugate

Our custom-synthesized multivalent linkers are designed with flexibility in mind. The conjugation chemistry can be tailored to diverse reaction types, expanding your target design space and opening new possibilities for oligonucleotide conjugate development.

Interested in exploring how our custom multivalent linkers can advance your oligonucleotide therapeutics and conjugate delivery programs?

Feel free to reach out to discuss your needs or request further details – we look forward to partnering with you on innovative drug discovery and development.