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HitGen has established a drug discovery research platform for small molecules and nucleic acid drugs centered on the design, synthesis and screening of DNA encoded chemical libraries (DELs), fragment-based drug discovery (FBDD) and structure-based drug design (SBDD) technologies.

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Publications

04 January 2026

A Mild Intramolecular Cyclization for the Synthesis of N–O Heterocycles and Unlocked Nucleic Acid Analogs
28 October 2025

Model-Assisted Process Optimization for Trivalent Ligand-siRNA Conjugation via CuAAC Click Chemistry

ACS Omega 10.1021/acsomega.5c09358
19 April 2024

The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening

Bioorganic & Medicinal Chemistry Letters 10.1016/j.bmcl.2024.129675
26 April 2023

Carbohydrate−DNA Conjugation Enabled by Glycosyl Radicals Generated from Glycosyl Sulfinates

Org Lett. 10.1021/acs.orglett.3c00833
14 March 2023

Expanding the DNA-encoded library toolbox: identifying small molecules targeting RNA

Nucleic Acids Res. https://doi.org/10.1093/nar/gkac173
06 January 2023

Optimization of PROTAC Ternary Complex Using DNA Encoded Library Approach

ACS Chem Biol. 10.1021/acschembio.2c00797
26 August 2022

PAC-FragmentDEL – photoactivated covalent capture of DNA-encoded fragments for hit discovery

RSC Med. Chem. 10.1039/d2md00197g
11 April 2022

Palladium-Mediated Hydroamination of DNA-Conjugated Aryl Alkenes

Frontiers in Chemistry 10.3389/fchem.2022.851674
01 April 2022

Photoredox Deaminative Alkylation in DNA-Encoded Library Synthesis

Organic Letters 2022 24 (14), 2650-2654 DOI: 10.1021/acs.orglett.2c00697
24 August 2021

A Novel Scalarized Scaffold Hopping Algorithm with Graph-Based Variational Autoencoder for Discovery of JAK1 Inhibitors

ACS Omega:A Novel Scalarized Scaffold Hopping Algorithm with Graph-Based Variational Autoencoder for https://doi.org/10.1021/acsomega.1c03613

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For more details on how we can advance your innovative drug discovery projects

Sites: HitGen Inc.

Building C2, NO.8, Huigu 1st East Road
Tianfu International Bio-Town,
Shuangliu District, Chengdu City,
Sichuan Province,P.R. China

Tel : +86-28-8519-7385

HitGen Pharmaceuticals Inc.(US Subsidiary)

Tel : +1-(508)-840-9646

Vernalis (R&D) Limited (UK Subsidiary)

Granta Park,Great Abington
Cambridge,CB21 6GB
United Kingdom

Tel : +44(0)1223-895555

Contact: Business Inquiry : bd@hitgen.com; Investor Relations : investors@hitgen.com; Media : media@hitgen.com; Career and Jobs : human.resources@hitgen.com; Supplier Collaboration : supplier@hitgen.com