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04.24
DEL Insight | HitGen Introduces CycWeave, a Token-Free Dual-View Graph Framework for Cyclic Peptidomimetics and DEL Modeling
Recently, the Computational Chemistry team at HitGen introduced CycWeave, a token-free dual-view coarse-grained graph neural framework designed for complex modular molecular systems. By adopting a representation strategy that better matches the modular nature of CPMs and DNA-encoded library (DEL) compounds, CycWeave demonstrated robust and competitive performance in both CPM membrane permeability prediction and large-scale DEL enrichment modeling.
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04.10
DEL Insight | Solid-phase DEL: Applications and Future Prospects
As the field of traditional DNA-Encoded Library (DEL) chemistry reaches maturity, expectations for library quality have become increasingly exacting. Beyond conventional optimizations focused on purification protocols and reaction yields, a growing number of research groups have pioneered solid-phase synthesis strategies to enhance peptide library purity. Here, we present and discuss the key insights gleaned from three recent publications on solid-phase DEL derivatives.
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03.31
DEL Insight | DNA-Encoded Libraries (DELs) for Discovering New Molecular Probes: Application to Live-Cell Bioimaging and Personalized Theranostics
A recent review published in Bioconjugate Chemistry by Marinier et al. (2026) shows that DNA-encoded libraries (DELs), long established for therapeutic small-molecule discovery, represent an underutilized yet highly promising platform for the rapid, parallel development of next-generation molecular probes – particularly for live-cell imaging, targeted radioimaging, and personalized theranostics. DEL-derived targeting moieties can be efficiently and modularly converted into high-affinity, high-selectivity optical or radiolabeled probes – including dual-use agents that simultaneously enable precise diagnosis and effective therapy (Figure 1).
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03.11
Leveraging HitGen DEL Technology to Unlock a Challenging Target for Inflammatory Disease Therapy
The recent Cell publication by Xavier et al. (2026) demonstrates a groundbreaking “binder-first” strategy to target the immune scaffold protein CARD9 – a historically “undruggable” protein due to its coiled-coil (CC) domain architecture. This work highlights how DNA-encoded library (DEL) technology, provided by HitGen, played an important role in identifying a ligandable site and enabling the discovery of functional inhibitors with therapeutic potential for Crohn’s disease and inflammatory bowel disease (IBD).
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