It is with great sadness that we hear of the passing of Professor Richard A Lerner. Richard served as the director of the Scripps Research Institute from 1991 until 2012, and in 1992 published the seminal paper in PNAS describing the concept of recording a series of chemical transformations by a DNA “code” with his Scripps colleague and Nobel laureate Dr. Sidney Brenner (1927-2019).
Exploring Aldol Reactions on DNA and Applications to Produce Diverse Structures: An Example of Expanding Chemical Space of DNA-Encoded Compounds by Diversity-Oriented Synthesis.
Chem. Asian J. 2020, 15, 4033
A Method for Estimating Binding Affinity From Primary DEL Selection Data
Biochemical and Biophysical Research Communications Volume 533, Issue 2
A B2(OH)4-Mediated Synthesis of 2-Substituted Indazolone and Its Application in a DNA-Encoded Library
Org. Lett. 2020, 22, 16, 6277–6282
A Simple Method for Determining Compound Affinity and Chemical Yield From DNA-encoded Library Selections
Biochemical and Biophysical Research Communications Volume 527, Issue 1, 18 June 2020, Pages 250-256
Optimized Methods for IL-17A Refolding and anti-IL17A Fab Production for Co-Crystallization With Small Molecules