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Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible lung disease characterized by fibrotic tissue replacing normal lung parenchyma, leading to declined pulmonary function and dyspnea.
The bleomycin-induced pulmonary fibrosis model is widely used in scientific research to study the pathogenesis of pulmonary fibrosis and evaluate potential therapies. This model offers advantages such as high reproducibility, histopathological similarities to human pulmonary fibrosis, low cost, and operational simplicity. However, it exhibits acute and uneven fibrotic lesions, contrasting with the chronic progression and irreversibility of human IPF. Despite its limitations, this model remains indispensable in pulmonary fibrosis research and therapeutic development.
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