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C–S Coupling of DNA-Conjugated Aryl Iodides for DNA-Encoded Chemical Library Synthesis Release Time:2021-03-15

Abstract


Thioethers have been widely found in biologically active compounds, including pharmaceuticals. In this report, a highly efficient approach to on-DNA construction of thioethers via Cu-promoted Ullmann cross-coupling between DNA-conjugated aryl iodides and thiols is developed. This methodology was demonstrated with medium to high yields, without obvious DNA damage. This reported reaction has strong potential for application in DNA-encoded chemical library synthesis.


Bioconjugate Chem. 2021

https://doi.org/10.1021/acs.bioconjchem.1c00076

Link:https://pubs.acs.org/doi/10.1021/acs.bioconjchem.1c00076


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