Welcome to HitGen


做最具创新力的生物医药企业     用最先进的科学技术赋能创新药研发

  1. 关于我们
  2. 发表文章

RASS‐Enabled S/P−C and S−N Bond Formation for DEL Synthesis 发布时间:2020-02-12


DNA encoded libraries (DEL) have shown promise as a valuable technology for democratizing the hit discovery process. Although DEL provides relatively inexpensive access to libraries of unprecedented size, their production has been hampered by the idiosyncratic needs of the encoding DNA tag relegating DEL compatible chemistry to dilute aqueous environments. Recently reversible adsorption to solid support (RASS) has been demonstrated as a promising method to expand DEL reactivity using standard organic synthesis protocols. Here we demonstrate a suite of on‐DNA chemistries to incorporate medicinally relevant and C−S, C−P and N−S linkages into DELs, which are underrepresented in the canonical methods.

Angew. Chem. Int. Ed. 2020, 59, 7377


Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201915493



为了使您在浏览本网站时获得最佳的体验,您需同意我们对Cookies的使用。想要了解更多有关于Cookies的信息,请阅读我们的 隐私政策。