Medicinal chemistry projects began adapting and using DNA-encoded library technology not only for the hit-discovery process to produce high-quality hits, but also for the lead optimization process. DELs can rapidly expand millions to billions of member around a hit or lead compound to improve potency, selectivity or other drug-like properties.
To obtain best fragment combination and cover broader chemical space.
Focused DELs are designed and synthesized for specific target selection to optimize hit compounds in a timely manner.
Focused DELs may provide richer SAR information to guide MedChem optimization.
The focused DELs can also be used for other homologous target screening