Welcome to HitGen

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Enabling Innovative Drug Discovery with Advanced Technologies

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  2. Pharmacology

Pharmacology

In vitro pharmacology

Our in vitro pharmacology team has expertise across a variety of therapeutic areas, target types, assay formats and instrument, completed in vitro studies of three new drug IND applications, can offer services in preclinical studies and IND with all kinds of enzymatic assays, binding assays and cellular assays.


Enzymatic Assays

  • Light absorbance

  • Luminescence

  • Fluorescence intensity

  • HTRF and TR-FRET


Binding assays

  • Fluorescence polarization

  • ELISA

  • Alphascreen and AlphaLISA


Cellular assays

  • Cell viability, cell apoptosis, cell proliferation, cell cycle and cell death

  • Cell Migration Assay

  • Cell Invasion Assay

  • Cellular Uptake Assay

  • Cell co-culture Assay

  • Intracellular signaling: Calcium flux, Reporter Gene Assay

  • Protein expression: Western blotting , Immunostaining, Immunofluorescence, HTRF

  • Gene Knockdown by siRNA

  • Gene Knockout by CRISPR/Cas9

  • Stable cell line generation

  • FACS and high content imagine system


In vivo pharmacology

Our in vivo pharmacology team focuses on oncology and inflammation, completed in vivo pharmacology studies of two new drug IND applications, can offer services in preclinical studies and IND with all kinds of animal models.


Oncology

  • CDX models and SOC data

  • Syngeneic models with immune profile and SOC data


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