HitGen unique AI-based ADMET evaluation platform can help us select good lead candidates and optimize lead compounds to clinical candidates. By train model using its proved result can significantly reduce a load of later processes (e.g. clinical trials), saving tons of resources as well as time.
Basic ADME characters including metabolic stability, protein binding and permeability are generally evaluated in H2L phase to rule out compound with undesirable druggability, pointing out direction for further optimization. HitGen provides ADME study service for H2L phase, rapidly gives reliable data and accelerates the overall optimization process.
Microsomal Stability for Multiple Species (H, Ms, R, D, MK)
Plasma Protein Binding Screening for Multiple Species
PAMPA-Based Permeability Assay