Welcome to HitGen

Capabilities

One-stop Technology Platform to Accelerate Drug Discovery and Development

DMPK

Drug metabolism and pharmacokinetics (DMPK) study investigate the absorption, distribution, metabolism and excretion (ADME) character of drug with a variety of technologies, which provide data for optimization of drug to acquire desirable in vivo performance, as well as predicting the ADME of drug when dosing to human.


In vitro/in vivo DMPK tools are throughout used in drug development. Based on DNA encoded library-directed drug development, HitGen has built a fast, economic and high-throughput DMPK study platform to support different stages of drug development from hit screening, lead optimization towards PCC confirmation.


In vitro DMPK 

  • Microsomal stability for multiple species (H, Ms, R, D, MK)

  • Hepatocyte stability for multiple species (Ms, R, D, MK)

  • Microsome/Hepatocyte-based metabolite identification/GSH adduction

  • Plasma protein binding

  • Cell uptake and efflux

  • CYP450 inhibition assay

  • PAMPA-based permeability assay


In vivo DMPK 

  • General pharmacokinetics

  • Cassette PK screening for multiple compounds

  • In vivo metabolites identification 

  • Tissue distribution


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