Pharmacodynamics is used to detect drug effectiveness in drug discovery and Investigational New Drug (IND) applications process.
In vitro pharmacology
Our in vitro pharmacology team has expertise across a variety of therapeutic areas, target types, assay formats and instrument, are expert in all kinds of enzymatic assays, binding assays and cellular assays.
HTRF and TR-FRET
Alphascreen and AlphaLISA
Cell viability, cell apoptosis, cell proliferation, cell cycle and cell death
Cell Migration Assay
Cell Invasion Assay
Cellular Uptake Assay
Cell co-culture Assay
Intracellular signaling: Calcium flux, Reporter Gene Assay
Protein expression: Western blotting , Immunostaining, Immunofluorescence, HTRF
Gene Knockdown by siRNA
Gene Knockout by CRISPR/Cas9
Stable cell line generation
FACS and high content imagine system
In vivo pharmacology
Our in vivo pharmacology team focuses on oncology and inflammation, is experienced with disease model establishment and validation for efficacy screening, in vivo pharmacology profiling, PK/PD and MOA studies.
CDX models and SOC data
Syngeneic models with immune profile and SOC data