Welcome to HitGen

Capabilities

One-stop Technology Platform to Accelerate Drug Discovery and Development

  1. Capabilities
  2. Chemoinformatics

Chemoinformatics

HitGen uses a range of commercial and open source cheminformatics tools to support better chemical decisions. As the leadership of DNA encoded library and hit identification platform, we have established a series of capabilities to support our platform to handle DEL design, synthesize, selection and follow up hit optimization in a time- and space-efficient way.


  • Well established cheminformatics workflow to do data driven library design and building block selection


  • Physicochemical property filters, fingerprint clustering and diversity analysis are used to evaluate our proprietary libraries or design new high-quality DNA encoded library


  • ∼1012 DEL compound structure enumeration, storing and fast 2D similarity search


  • Track the experimental information in the library synthesis and the affinity selection to maximize scientific productivity and enhance the overall quality of DELs


  • DEL selection data mining for data-driven feature identification and hit proposal


  • DEL selection data for QSAR model building to predict new compound affinities or activities


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