Welcome to HitGen

Capabilities

One-stop Technology Platform to Accelerate Drug Discovery and Development

Capabilities
  1. Capabilities
  2. DNA-encoded Library

DNA-encoded Library

Since their initial conception concept was conceived in 1992 (Brenner, S., Lerner, R. A. Proc. Natl. Acad. Sci. 1992, 89, 5381-5383), DNA-encoded chemical libraries (DEL) have evolved into a valuable platform for hit identification in early drug discovery. Compounds in DELs consist of building blocks serving as diversity elements, which are encoded by unique DNA sequences as identification “barcodes,” and are assembled combinatorially in split-and-pool fashion via DNA-compatible reactions. 


The DEL technology enables the fast and economic synthesis, screening and analysis of DNA-encoded collections of millions to billions of compounds against biological targets through a confluence of molecular biology, combinatorial chemistry, high throughput sequencing and advanced informatics techniques. Compared to traditional high-throughput screening (HTS), DEL possesses multiple merits, including a much larger library size and more cost-efficient affinity screens. HitGen has been building a large collection of novel, diverse and drug-like DELs as its primary drug discovery platform.

DNA-encoded Library

Thanks for reading!

For more details on how we can advance your innovative drug discovery projects
验证码
By submitting your information, you acknowledge having received, read and understood our Privacy Notice as made available above.

We use cookies to provide a better web experience.
By using our site, you acknowledge our use of cookies and please read our Cookie Notice for More information