Over the last few years, we have solved over dozens of target protein-small molecule cocrystal structures. For each protein crystallography project, we accelerate data processing and structure solutions via automated programs, meanwhile, the essential steps, like ligand fitting and finalization of the structures, are performed manually by our experienced crystallographers.
Crystal structures will be solved with molecular replacement or advanced de novo phasing techniques, followed by a detailed comparative analysis of the protein co-crystal structures, with the important interactions and the ligand-induced conformational changes highlighted.
Our experts verify and interpret every single structure carefully before delivery. All structures delivered passed our quality control criteria, that is, the PDB standard.
X-Ray Diffraction and Structure Determination