Drug metabolism and pharmacokinetics (DMPK) study investigate the absorption, distribution, metabolism and excretion (ADME) character of drug with a variety of technologies, which provide data for optimization of drug to acquire desirable in vivo performance, as well as predicting the ADME of drug when dosing to human.
In vitro/in vivo DMPK tools are throughout used in drug development. Based on DNA encoded library-directed drug development, HitGen has built a fast, economic and high-throughput DMPK study platform to support different stages of drug development from hit screening, lead optimization towards PCC confirmation.
In vitro DMPK
Microsomal stability for multiple species (H, Ms, R, D, MK)
Hepatocyte stability for multiple species (Ms, R, D, MK)
Microsome/Hepatocyte-based metabolite identification/GSH adduction
Plasma protein binding
Cell uptake and efflux
CYP450 inhibition assay
PAMPA-based permeability assay
In vivo DMPK
Cassette PK screening for multiple compounds
In vivo metabolites identification