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  • 31 July 2023
    DEL for Protein Degradation
    Protein degraders (most popularly known as PROTAC or Molecular Glue) utilize an event-driven process, recruit protein of interest (POI, or targeted protein) and E3 ligase directly or indirectly, induce poly-ubiquitination of POI and subsequent proteasome-mediated degradation. Unlike protein inhibitors, protein degraders do not require inhibitory activity to the protein, therefore, this modality of therapeutics applies to broader target classes including undruggable proteins, scaffold proteins, mutant proteins and etc.
  • 04 December 2021
    Richard Lerner Remembrance
    It is with great sadness that we hear of the passing of Professor Richard A Lerner. Richard served as the director of the Scripps Research Institute from 1991 until 2012, and in 1992 published the seminal paper in PNAS describing the concept of recording a series of chemical transformations by a DNA “code” with his Scripps colleague and Nobel laureate Dr. Sidney Brenner (1927-2019).
  • 29 December 2020
    Exploring Aldol Reactions on DNA and Applications to Produce Diverse Structures: An Example of Expanding Chemical Space of DNA-Encoded Compounds by Diversity-Oriented Synthesis.
    Chem. Asian J. 2020, 15, 4033 https://doi.org/10.1002/asia.202001105
  • 03 December 2020
    A Method for Estimating Binding Affinity From Primary DEL Selection Data
    Biochemical and Biophysical Research Communications Volume 533, Issue 2 DOI: 10.1101/2020.05.04.077842
  • 01 August 2020
    A B2(OH)4-Mediated Synthesis of 2-Substituted Indazolone and Its Application in a DNA-Encoded Library
    Org. Lett. 2020, 22, 16, 6277–6282 https://doi.org/10.1021/acs.orglett.0c02032
  • 18 June 2020
    A Simple Method for Determining Compound Affinity and Chemical Yield From DNA-encoded Library Selections
    Biochemical and Biophysical Research Communications Volume 527, Issue 1, 18 June 2020, Pages 250-256 https://doi.org/10.1016/j.bbrc.2020.04.024
  • 27 April 2020
    Optimized Methods for IL-17A Refolding and anti-IL17A Fab Production for Co-Crystallization With Small Molecules
    BIOTECHNIQUESVOL. 69, NO. 1 https://doi.org/10.2144/btn-2019-0170
  • 10 April 2020
    Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library
    ACS Med. Chem. Lett. 2020, 11, 6, 1175–1184 https://doi.org/10.1021/acsmedchemlett.0c00029
  • 02 April 2020
    Photocatalytic [2 + 2] Cycloaddition in DNA-Encoded Chemistry
    Org. Lett. 2020, 22, 8, 2908–2913 https://doi.org/10.1021/acs.orglett.0c00574
  • 30 January 2020
    Synthesis of Multifunctional 2-Aminobenzimidazoles on DNA via Iodine-Promoted Cyclization
    Org. Lett. 2020, 22, 4, 1290–1294 https://doi.org/10.1021/acs.orglett.9b04578

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